 Reference Base  Red blood cell enzymes in the black rhinoceros (Diceros b... |
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Worley, M.B.; Carpenter, A.C., 1995. Red blood cell enzymes in the black rhinoceros (Diceros bicornis): initial molecular studies of catalase. Verhandlungsbericht des Internationalen Symposiums uber die Erkrankungen der Zootiere 37: 41-45, tables 1-2
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| Location: |
Africa |
| Subject: |
Diseases |
| Species: |
Black Rhino |
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The enzyme catalase may play a pivotal role in the pathogenesis of acute episodic hemolysis in the black rhino. We constructed a black rhino fibroblast cDNA librray and screened for catalase sequences with a human catalase cDNA probe. The DNA sequence of a positive clone that represented 86% of the coding region of the catalase gene was determined. The translated amino acid sequence was 90-95% homologous to bovine, human, mouse and rat catalase sequences. A hypervariable region of 16 amino acids was only 37.5 % identical between black rhino and human sequences. This result may offer a possible explanation for the finding that catalase activity in black rhino erythrocytes is only 2-3% of that found in human erythrocytes.
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